Hydrochloride Donepezil Intermediate for The Preparation of Apis

• Customization: Available
• Powder: Yes
• Customized: Customized
• Model NO.: Customized on demand
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Solid
• Purity: >99%
• Molecular Formula: C17h24clno3
• Transport Package: According to Customer Requirements
• Specification: 25kg/drum
• Trademark: none
• Origin: China

Product Description

Donepezil has a reversible and non-competitive inhibitory effect on AChE. It is 500-1000-fold more selective for AChE than for BuChE. Short- and long-term drug exposure to human SH-SY5Y neuroblastoma cells induces a concentration-dependent inhibition of cell proliferation independent of muscarinic or nicotinic receptor blockade and apoptosis. Donepezil reduces the number of cells in the S-G2/M phase of the Cell Chemicalbook cycle, increases the number of cells in the G0/G1 phase, and reduces the expression of two cyclins in the G1/S and G2/M transitions: cyclinE and cyclinB. At the same time, it also increased the expression of the cell cycle repressor p21. In addition, donepezil increases action potential-dependent dopamine release and modulates nicotinic receptors in substantia nigra dopaminergic neurons.

 

Donepezil hydrochloride intermediate II is used to produce donepezil hydrochloride API, cas120013-39-0