Donepezil for The Preparation of Alzheimer′s Disease

• Customization: Available
• Function: Hormones and Regulation of Endocrine Function of Drug, Antibiotic and Antimicrobial Agents, Original Drug Resistant Microbes, Immune System Drugs, Specialist Drugs, Drug Detoxification, Diagnostic Agents, Nervous System Drugs, Blood System Agents, Central Nervous System Agents, Antidote, Respiratory System Agents, Disinfectant and Preservatives
• Certification: GMP, Reach, FDA
• Model NO.: Customized on demand
• Grade Standard: Medicine Grade
• Type: Chemical Reagent
• State: Solid
• Volatile: Not Volatile
• Transport Package: According to Customer Requirements
• Specification: 1kg/piece
• Trademark: none
• Origin: China

Product Description

 

 

 

FAQ

Q: When can I get the price?
A: We usually quote within 24 hours after we get your inquiry.
    If you are very urgent to get the price, please tell us so that we will regard your inquiry priority.

Q: How can I get a sample to check your quality?
A: After price confirmation, we are happy for sending samples in 2 days to you once you need.

Q: What about the lead time for mass production?
A: Honestly, it depends on the order quantity and the season you place the order. Usually it takes 45days.

Q: What is your terms?
A: We accept EXW, FOB, CFR, CIF, DDU, DDP, etc. 
    You can choose the one which is the most convenient or cost effective for you.

 

 

 

FAQ

Q: When can I get the price?
A: We usually quote within 24 hours after we get your inquiry.
    If you are very urgent to get the price, please tell us so that we will regard your inquiry priority.

Q: How can I get a sample to check your quality?
A: After price confirmation, we are happy for sending samples in 2 days to you once you need.

Q: What about the lead time for mass production?
A: Honestly, it depends on the order quantity and the season you place the order. Usually it takes 45days.

Q: What is your terms?
A: We accept EXW, FOB, CFR, CIF, DDU, DDP, etc. 
    You can choose the one which is the most convenient or cost effective for you.

Donepezil has a reversible and non-competitive inhibitory effect on AChE. It is 500-1000-fold more selective for AChE than for BuChE. Short- and long-term drug exposure to human SH-SY5Y neuroblastoma cells induces a concentration-dependent inhibition of cell proliferation independent of muscarinic or nicotinic receptor blockade and apoptosis. Donepezil reduces the number of cells in the S-G2/M phase of the cell cycle, increases the number in the G0/G1 phase, and reduces the expression of two cyclins in the G1/S and G2/M transitions: cyclinE and cyclinB. At the same time, it also increased the expression of the cell cycle repressor p21. In addition, donepezil increases action potential-dependent dopamine release and modulates nicotinic receptors in substantia nigra dopaminergic neurons. In vivo studies Donepezil is slowly absorbed from the gastrointestinal tract in vivo, with a terminal half-life of 50-70 hours in young volunteers, and a half-life of more than 100 hours in the elderly. After extensive hepatic metabolism, the parent compound is 93% bound to plasma proteins. Donepezil is metabolized in the liver by the cytochrome P450 system (CYP1A2-, CYP2D6-, CYP3A4-related enzymes). In animals, donepezil was unchanged in the brain and no metabolites were found in neural tissue. In plasma, urine and bile, most donepezil metabolites are O-glucuronides. After oral ingestion, peak plasma concentrations are reached within 3-5 hours, and its absorption is not affected by food. Donepezil has linear pharmacokinetics in the concentration range of 1-10 mg/day. 96% of circulating donepezil is protein bound. Uses Donepezil hydrochloride monohydrate is a centrally reversible acetylcholinesterase inhibitor.

NO.API		CAS NO.	Quality     Standard	DMF
1,Antibiotics
	Ceftizoxime Sodium	68401-82-1	CP,USP,JP
2	Cefoxitin Sodium	33564-30-6	USP,EP,BP,CP
3	Cefotiam Hydrochloride	66309-69-1	JP,USP.IH
4	Cefazedone Sodium	63521-15-3	KP,YBH
5	Cefoperazone Sodium	62893-20-3	CP,USP,EP,BP,JP
6	Sulbactam Sodium	69388-84-7	EP,USP,BP,KP,CP
7	Cefoperazone Sodium andSulbactam Sodium (1:1) 1:1		.H
8	Cefuroxime Sodium	56238-63-2	EP,USP,JP,BP,CP,IP,KP
9	Ceftezole Sodium	41136-22-5	CP	√
10	Cefamandole Nafate	42540-40-9	USP,EP,BP,CP
11	Cefepime Hydrochloride with Arginine()	107648-80-6	USP,CP,IP	√
12	Biapenem	120410-24-4	I.H
13	Aztreonam()	78110-38-0	CP,IP	√
II,Cardiovascular and Cerebral System APIs
1	Tirofiban Hydrochloride	150915-40-5	I.H	√
2	Ticagrelor	274693-27-5	l.H	Preparing
3	Rivaroxaban	366789-02-8	I.H	√
4	Edaravone	89-25-8	JP,CP
5	Donepezil Hydrochloride	120011-70-3	USP,EP,JP,CP	Preparing
6	Carbazochrome Sodium Sulfonate	51460-26-5	JP,I.H
	Vildagliptin	274901-16-5	I.H
II,Others
1	Omeprazole Enteric-coated Pellets ()	73590-58-6	I.H
2	Loxoprofen Sodium	80382-23-6	JP,KP,I.H	√
3	Parecoxib Sodium	198470-85-8	I.H	√
4	Ambroxol Hydrochoride	23828-92-4	EP,BP.CP	√
5\			USP,EP,I.H
6	Gemcitabine Hydrochloride	122111-03-9	USP,EP,BP,CP	√
IV,Intermediate
1	Tirofiban Hydrochloride Intermediate II	149490-61-9
	Tirofiban Hydrochloride Intermediatell	144494-65-5
	Tirofiban Hydrochloride IntermediatellII	150915-40-5
2	Rivaroxaban Intermediate I1	446292-07-5
	Rivaroxaban Intermediate I	446292-08-6
	Rivaroxaban IntermediateIII	898543-06-1
3	Vildagliptin Intermediate II	214398-99-9
	Vildagliptin Intermediatell	207557-35-5
4	Loxoprofen Acid	68767-14-6
	TadalafilIntermediate II	14907-27-8
6	Cefazolin	25953-19-9
	Cefoperazone	62893-19-0
8	Cefazedone	56187-47-4
	7-TDA	30246-33-4
9	Cefoxitin	35607-66-0