Tirofiban Hydrochloride for The Preparation of Anti-Angina Pectoris Drugs

• Customization: Available
• Function: Nutritional Therapeutics, Antineoplastic, Antiparasitic, Original Drug Resistant Microbes, Immune System Drugs, Specialist Drugs, Drug Detoxification, Diagnostic Agents, Nervous System Drugs, Blood System Agents, Enzymes and Other Biochemical, Visceral System Medication, Central Nervous System Agents, Cardiovascular Agents, Disinfectant and Preservatives
• Certification: GMP, Reach, FDA
• Model NO.: Customized on demand
• Grade Standard: Medicine Grade
• Type: Chemical Reagent
• State: Solid
• Volatile: Not Volatile
• Transport Package: According to Customer Requirements
• Specification: Customized on demand
• Trademark: none
• Origin: China

Product Description

Tirofiban hydrochloride is tirofiban hydrochloride. Tirofiban is an anti-angina drug successfully developed by Merck Company in the United States. It is clinically used in combination with heparin to treat acute coronary syndromes, including patients with unstable angina or non-Q-wave myocardial infarction, and patients undergoing percutaneous transluminal coronary angioplasty (PTCA) or atherectomy. At present, the main drugs in clinical use are tirofiban hydrochloride injection, the trade name is Xinweining, which is a reversible non-peptide platelet surface glycoprotein (GP) IIb/IIIa receptor antagonist, which can competitively inhibit the Binding of fibrinogen to blood Chemicalbook platelet (GP) IIb/IIIa receptors. Intravenous injection, it can dose-dependently inhibit platelet aggregation in vitro caused by ADP, collagen, arachidonic acid, thromboxane analog U46619 and thrombin, prolong bleeding time, and inhibit thrombosis. In healthy volunteers, at the routine recommended dose, the peak plasma concentration is similar to the steady-state plasma concentration during intravenous infusion. T1/2 is 2h. In the dose range of 0.01 ~ 25μg/ml, the PPB of this product is 65%, regardless of concentration. Free drug accounts for 35% of plasma, Vd is 22 ~ 42L. In healthy volunteers, CL was 213-314 ml/min, and renal clearance accounted for 39%-69% of plasma clearance.

Shandong Luoxin Pharmaceutical Group HENGXIN Pharmaceutical Co., Ltd. is one of the subsidiaries of Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.(Luoxin Group), responsible for the export business of all products from Luoxin Group and others agent products.
Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. is a healthcare conglomerate that is engaged in pharmaceutical research and development, manufacture, sales, and healthcare service. There are six manufacturing sites covering formulations, APIs and Intermediates, Chinese medicine and its extracts and Medical apparatus and instruments products. 
Benefiting from the layout structure of the whole industry chain, Luoxin Pharmaceutical has a strong development momentum and successfully listed on the A-share market in 2019.

 

API PRODUCT LIST
NO.	Product Name	CAS NO.	Quality Standard	DMF
A. Antibiotics
1	Ceftizoxime Sodium	68401-82-1	CP, USP, JP	√
2	Cefoxitin Sodium	33564-30-6	USP, EP, BP, CP	√
3	Cefotiam Hydrochloride	66309-69-1	JP, USP, I.H	√
4	Cefazedone Sodium	63521-15-3	KP, YBH	√
5	Cefoperazone Sodium	62893-20-3	CP, USP, EP, BP, JP	√
6	Sulbactam Sodium	69388-84-7	EP, USP, BP, KP, CP	√
7	Cefoperazone Sodium and Sulbactam Sodium (1:1)	--	I.H	√
8	Cefuroxime Sodium	56238-63-2	EP, USP, JP, BP, CP, IP, KP	√
9	Ceftezole Sodium	41136-22-5	CP	√
10	Cefamandole Nafate	42540-40-9	USP, EP, BP, CP	√
11	Cefepime Hydrochloride with Arginine	107648-80-6	USP, CP, IP	√
12	Biapenem	120410-24-4	I.H	√
13	Aztreonam	78110-38-0	CP ,IP	√
B. Cardiovascular and Cerebral System APIs
1	Tirofiban Hydrochloride	150915-40-5	I.H	√
2	Ticagrelor	274693-27-5	I.H	√
3	Rivaroxaban	366789-02-8	I.H	√
4	Edaravone	89-25-8	JP, CP	√
5	Donepezil Hydrochloride	120011-70-3	USP, EP, JP, CP	√
6	Carbazochrome Sodium Sulfonate	51460-26-5	JP, I.H	√
7	Vildagliptin	274901-16-5	I.H	√
C. Others
1	Omeprazole Enteric-coated Pellets	73590-58-6	I.H
2	Loxoprofen Sodium	80382-23-6	JP, KP, I.H	√
3	Parecoxib Sodium	198470-85-8	I.H	√
4	Ambroxol Hydrochloride	23828-92-4	EP, BP, CP	√
5	Gemcitabine Hydrochloride	122111-03-9	USP, EP, BP, CP	√
D.Intermediate
1	Tirofiban Hydrochloride Intermediate	149490-61-9
	Tirofiban Hydrochloride Intermediate	144494-65-5
	Tirofiban Hydrochloride Intermediate	150915-40-5
2	Rivaroxaban Intermediate	446292-07-5
	Rivaroxaban Intermediate	446292-08-6
	Rivaroxaban Intermediate	898543-06-1
3	Vildagliptin Intermediate	214398-99-9
	Vildagliptin Intermediate	207557-35-5
4	Loxoprofen Acid	68767-14-6
5	Cefazolin	25953-19-9
6	Cefoperazone	62893-19-0
7	Cefazedone Sodium	56187-47-4
	7-TDA	30246-33-4
8	Cefoxitin	35607-66-0